DEPAKINE (CHRONO) 500 MG 30 TAB Details
|* DEPAKINE CHRONO (Valproic acid and sodium valproate) 500 mg 30 prolonged-release scored film-coated tablets.|
|* Composition: Excipients q.s.f. one tablet:|
|Sodium valproate 333 mg + Valproic acid 145 mg.......... quantity corresponding to: Sodium valproate 500 mg.|
|* Prescription Only Medicine. List II. Oral use.|
|* Read carefully the package insert before use. Use the dose as prescribed.|
|* Be very careful: Do not drive without asking a health professional's opinion.|
|* Store below 25 degrees C, protected from moisture (humidity).|
|* Manufacturer: Sanofi Winthrop Industrie (Sanofi-Synthelabo) - France. استيراد: رامكو|
|Marketing Authorization Holder: sanofi-aventis France (1-13, boulevard Romain Rolland, 75014 Paris) - France. استيراد: رامكو|
Depakine Chrono 500 mg. 30 tablets
What Depakine Chrono?
1 tablet of 500 mg contains active substances - 333 mg of sodium valproate and valproic acid 145 mg.
Excipients include: ethyl cellulose, hypromellose, colloidal anhydrous silica, hydrated colloidal silica, saccharin sodium, polyacrylate, Macrogol 6000, talc and titanium dioxide.
How does Depakine Chrono?
The mechanism of action is not completely understood, but it is assumed that Depakine Chrono prevents or blocks impulses in the brain that start epileptic seizures.
What is Depakine Chrono?
Depakine chrono is used to treat epilepsy and manic conditions, maintenance and preventive treatment of bipolar disorder.
Do not take Depakine Chrono:
• if you have impaired liver function
• if you suffer from porphyria (increased excretion of certain pigments in the blood)
• in the event of a hypersensitivity towards any of the ingredients of Depakine Chrono.
To be given before or during the adoption of Depakine Chrono.
Treatment with Depakine Chrono requires careful monitoring of liver and pancreatic function and blood. It is important to appear in control reviews. This is particularly important at the beginning of treatment and surgeries. If you suffer from blood disorder, certain skin diseases (systemic lupus erythematosus), impaired renal function, any disease of metabolism (especially diseases, disorders associated with enzyme deficiency), or if you bruise easily or bleeding The doctor should be notified. You should always carefully follow the advice of your doctor! If you are not sure about something, consult your lekar.Sashtestvuva risk should gain weight while taking Depakine chrono. If you need help to adjust the weight, consult your doctor. You must check with your doctor if any of the following symptoms: loss of appetite, nausea, drowsiness and fatigue, Conto sometimes accompanied by repeated vomiting or abdominal pain, jaundice, edema of the legs shi feet, and in the case that suddenly deteriorate mastery of your seizures. This is particularly important in children during the first six months of treatment. Do not stop taking the drug abruptly, which may cause seizures increase. Do not change your dose without consulting your doctor.
If you are pregnant or planning to become pregnant, talk to your doctor. The likelihood of harm to the fetus. Therefore, do not use Depakine chrono during pregnancy unless your doctor has prescribed so.
Depakine Chrono passes into breast milk, but probably does not harm the infant. Consult your doctor if you are breast-feeding taking Depakine Chrono not only temporarily.
Your sole responsibility to decide whether you are able to drive a car or perform hazardous work. One of the factors that can affect your ability, is taking drugs because of their action and / or side effects (adverse reactions). These actions and side effects are described in other sections of this leaflet. Therefore, you should read all the information in the leaflet to get directions. If you are unsure, consult your doctor.
What should be avoided when taking this medicine?
The effect of treatment can be influenced if Depakine chrono is taken with certain medicines for pain (acetylsalicylic acid - aspirin), gastric ulcer (cimetidine), coronary heart disease (nimodipine), epilepsy (ethosuximide, felbamate, phenobarbital, phenytoin, carbamazepine , lamotrigine, primidone), agitation (lorazepam), some anticoagulants (warfarin), certain antimalarial drugs (mefloquine), viral infections (zidovudine), certain antibiotics (erythromycin, carbapenems as ertapenem, imipenem, meropenem, panipenem) and drugs against depression . Treatment with antibiotics containing pivalic acid (pivampicillin, pivmetsilinam) should be avoided. Other medicines may also be influenced by Depakine Chrono. The doctor should know about any type of concomitant medications that vzemate.Zaedno treatment should not consume alcohol as Depakine Chrono enhances the action of alcohol.
The dose is determined by the doctor and is adjusted individually for you.
Epilepsy: The daily dose may vary depending on the age, body weight and severity of seizures.
The usual adult dose is 20-30 mg / kg body weight per day. This in most patients corresponds to 2-6 tablets of 500 mg divided by 1-2 taken daily. If desired, tablets can be administered to children. The usual dose for children is 30 mg / kg body weight dnevno.Tabletkite can be divided, but should not be chewed or strivat.Ne stop treatment without consulting their doctor. Otherwise your condition may get worse.
Instructions for use
The tablets are provided in vials, where half of the tablets can be stored in a small container situated in the cap. Since tablets are sensitive to moisture, the vial is fitted with a tightly fitting cap that should always be well zatvorena.Kakvo happens if you take too much? If you take excessive amounts of medicine, immediately contact your physician or hospital.
Adverse events (side effects)
Common (more than 1 in 100 patients): Stomach problems, such as pain, hiccups, nausea, vomiting and diarrhea. Increased appetite, abnormal weight gain, loss of appetite and weight loss. Trembling. Increased bleeding tendency due to decreased number of blood platelets (thrombocytopenia). This is usually transient. Affect liver function changes in liver function tests.
Low frequency: Changes in behavior and difficulty sleeping. Unsteady gait. Incontinence in little need or often walking in a small need. Depakine chrono when combined with other anti-epileptics, may occur fatigue. Can start hair loss and discoloration of hair. Irregular or absent menstruation. Severe liver damage, sometimes deadly. This rule applies to young children with multiple disabilities, who are treated with high doses in combination with other anti-epileptics and less self-administered Depakine Chrono.
Rare (less than 1 in 1000 patients): Headache, numbness and feeling of ants crawling on the skin, impaired coordination. Severe cases of bleeding tendency (thrombocytopenia), severe cases of low white blood cells (leukopenia) and bleeding. Skin rash (sometimes heavy). Psychosis, confusion. Transitional dementia, parkinsonism transition. Constipation, inflammation of the pancreas. Swelling of the legs and feet (edema). Decreased body temperature. Severe hepatic impairment in older children. Inflammation of blood vessels (vasculitis). Impaired renal function (Syndrome Fanconi). Also, mogatvazniknat hearing problems and allergic reactions.
Reported reduced amount of sodium in kravta.Ako notice any side effects not listed in this leaflet, please tell your doctor.